Roflumilast partially reverses smoke-induced mucociliary dysfunction

Abstract

BACKGROUND Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway epithelial cells, PDE4 inhibitors can stimulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by increasing cAMP. Tobacco smoking and COPD are associated with decreased CFTR function and… (More)
DOI: 10.1186/s12931-015-0294-3

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Cite this paper

@inproceedings{Schmid2015RoflumilastPR, title={Roflumilast partially reverses smoke-induced mucociliary dysfunction}, author={Andreas Schmid and Nathalie Baumlin and Pedro I Ivonnet and John S. Dennis and M Soledad Campos and Stefanie Krick and Matthias A. Salathe}, booktitle={Respiratory research}, year={2015} }