Roflumilast partially reverses smoke-induced mucociliary dysfunction

  title={Roflumilast partially reverses smoke-induced mucociliary dysfunction},
  author={Andreas Schmid and Nathalie Baumlin and Pedro I Ivonnet and John S. Dennis and Michael A Campos and Stefanie Krick and Matthias A. Salathe},
  booktitle={Respiratory research},
BACKGROUND Phosphodiesterases (PDEs) break down cAMP, thereby regulating intracellular cAMP concentrations and diffusion. Since PDE4 predominates in airway epithelial cells, PDE4 inhibitors can stimulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by increasing cAMP. Tobacco smoking and COPD are associated with decreased CFTR function and impaired mucociliary clearance (MCC). However, the effects of the PDE4 inhibitor roflumilast on smoke-induced mucociliary dysfunction have not… CONTINUE READING
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Roflumilast Inhibits Il-13-Induced Mucous Metaplasia In Airway Epithelium

  • SM Kreda, T Nguyen, L Moussa, M Alonso-Galicia, M Qian, J. Freire
  • Am J Respir Crit Care Med
  • 2014
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