Roflumilast Inhibits Respiratory Syncytial Virus Infection in Human Differentiated Bronchial Epithelial Cells

@inproceedings{Mata2013RoflumilastIR,
  title={Roflumilast Inhibits Respiratory Syncytial Virus Infection in Human Differentiated Bronchial Epithelial Cells},
  author={Manuel Mata and Isidoro Mart{\'i}nez and Jos{\'e} A Melero and Herman Tenor and Julio Cortijo},
  booktitle={PloS one},
  year={2013}
}
Respiratory syncytial virus (RSV) causes acute exacerbations in COPD and asthma. RSV infects bronchial epithelial cells (HBE) that trigger RSV associated lung pathology. This study explores whether the phosphodiesterase 4 (PDE4) inhibitor Roflumilast N-oxide (RNO), alters RSV infection of well-differentiated HBE (WD-HBE) in vitro. WD-HBE were RSV infected… CONTINUE READING