Rofecoxib

@article{Hillson2000Rofecoxib,
  title={Rofecoxib},
  author={Jan Hillson and Daniel E. Furst},
  journal={Expert Opinion on Pharmacotherapy},
  year={2000},
  volume={1},
  pages={1053 - 1066}
}
Rofecoxib (Vioxx™, Merck & Co., Inc.) is a new orally-effective non-steroidal anti-inflammatory drug (NSAID) approved for treatment of acute pain, fever, primary dysmenorrhea and pain and inflammation in osteoarthritis (OA). It is also being evaluated for treatment of rheumatoid arthritis and adenomatous polyps of the colon. Rofecoxib is a specific inhibitor of cyclooxygenase-2 (COX-2), thereby inhibiting prostanoid synthesis in cells that express COX-2, including inflammatory cells. As cells… 
3 Citations
Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach
TLDR
Future in vitro and in vivo studies are needed to confirm the anti-inflammatory potential of the compounds selected here with bioinformatics approaches based on rofecoxib ligand, which showed satisfactory pharmacokinetic results related to absorption and distribution.
The System Research of the Molecular Mechanism of Quyushengxin Capsule in the Treatment of Osteonecrosis of the Femoral Head
TLDR
An integrated approach was used to investigate the mechanism of QYSXC in the treatment of ONFH, which contained systems pharmacology, molecular docking, and chip experiment to provide a theoretical basis for further research on the molecular mechanism.

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