Rodlike complexes of a polyelectrolyte (hyaluronan) and a protein (lysozyme) observed by SANS.

  title={Rodlike complexes of a polyelectrolyte (hyaluronan) and a protein (lysozyme) observed by SANS.},
  author={Isabelle Morfin and Eric Buhler and Fabrice Cousin and Isabelle Grillo and François Bou{\'e}},
  volume={12 4},
We study by small-angle neutron scattering (SANS) the structure of hyaluronan -lysozyme complexes. Hyaluronan (HA) is a polysaccharide of 9 nm intrinsic persistence length that bears one negative charge per disaccharide monomer (M(mol) = 401.3 g/mol); two molecular weights, M(w) = 6000 and 500,000 Da were used. The pH was adjusted at 4.7 and 7.4 so that lysozyme has a global charge of +10 and +8, respectively. The lysozyme concentration was varied from 3 to 40 g/L at constant HA concentration… 

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