Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions.

@article{Maliqueo2014RodentMO,
  title={Rodent models of polycystic ovary syndrome: phenotypic presentation, pathophysiology, and the effects of different interventions.},
  author={M Manuel Maliqueo and Anna Benrick and Elisabet Stener-Victorin},
  journal={Seminars in reproductive medicine},
  year={2014},
  volume={32 3},
  pages={183-93}
}
This review focuses on rodent models exposed to sex steroids prepubertally and describes their phenotypes and pathophysiology with specific focus on the estradiol valerate-, dihydrotestosterone-, and letrozole-induced rat polycystic ovary syndrome (PCOS) models. Phenotypic presentations are compared among models as a function of the timing and dose of the exposure. Furthermore, the use of these models to study the possible effects and mechanisms of different treatment modalities relevant for… CONTINUE READING

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