Rodent models of hepatic ischemia-reperfusion injury: time and percentage-related pathophysiological mechanisms.

@article{Karatzas2014RodentMO,
  title={Rodent models of hepatic ischemia-reperfusion injury: time and percentage-related pathophysiological mechanisms.},
  author={Theodore M. Karatzas and A Neri and Maria-Eleni E Baibaki and Ismene A. Dontas},
  journal={The Journal of surgical research},
  year={2014},
  volume={191 2},
  pages={399-412}
}
Ischemia and reperfusion (IR) injury remains one of the major problems in liver surgery and transplantation, which determines the viability of the hepatic tissue after resection and of the grafted organ. This review aims to elucidate the mechanisms involved in IR injury of the liver in rodent experimental studies and the preventative methods and pharmacologic agents that have been applied. Many time- and percentage-related liver IR injury rodent models have been used to examine the… CONTINUE READING

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