Rodent models for human polycystic ovary syndrome.

  title={Rodent models for human polycystic ovary syndrome.},
  author={Kirsty A. Walters and Charles M. Allan and David J Handelsman},
  journal={Biology of reproduction},
  volume={86 5},
  pages={149, 1-12}
Polycystic ovary syndrome (PCOS) is the most frequent female endocrine disorder, affecting 5%-10% of women, causing infertility due to dysfunctional follicular maturation and ovulation, distinctive multicystic ovaries and hyperandrogenism, together with metabolic abnormalities including obesity, hyperinsulinism, an increased risk of type 2 diabetes, and cardiovascular disease. The etiology of PCOS is unclear, and decisive clinical studies are limited by ethical and logistic constraints… CONTINUE READING
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