Rodent models for Alzheimer's disease drug discovery.

@article{Puzzo2015RodentMF,
  title={Rodent models for Alzheimer's disease drug discovery.},
  author={Daniela Puzzo and Walter Gulisano and Agostino Palmeri and Ottavio Arancio},
  journal={Expert opinion on drug discovery},
  year={2015},
  volume={10 7},
  pages={
          703-11
        }
}
INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia. Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein in neurofibrillary tangles in the brain. Rare forms of early onset familial Alzheimer's disease are due to gene mutations. This has prompted researchers to develop genetically modified animals that… CONTINUE READING
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