Rodent model systems for studies of HIV-1 associated dementia

  title={Rodent model systems for studies of HIV-1 associated dementia},
  author={Yuri Persidsky and Raghava Potula and James Haorah},
  journal={Neurotoxicity Research},
Understanding of HIV-1 neuropathogenesis and development of rationale therapeutic approaches requires relevant animal models. The putative mechanisms of neuroinflammatory and neurotoxic events triggered by HIV-1 brain infection are reflected by a number of rodent models. These include transgenic animals (either expressing viral proteins or pro-inflammatory factors), infection with murine retroviruses, and severe combined immunodeficient (SCID) mice reconstituted with human lymphocytes and… CONTINUE READING

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