Rodent diet aids and the fallacy of caloric restriction

@article{Wolf2021RodentDA,
  title={Rodent diet aids and the fallacy of caloric restriction},
  author={Alexander M. Wolf},
  journal={Mechanisms of Ageing and Development},
  year={2021},
  volume={200}
}
  • Alexander M. Wolf
  • Published 1 October 2021
  • Medicine, Biology
  • Mechanisms of Ageing and Development
2 Citations

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References

SHOWING 1-10 OF 330 REFERENCES

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD+ levels sustainably, and analysis of NAD+ in whole blood demonstrated that NRPT significantly increases the concentration of NAD+, in a dose-dependent manner.

The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of aging

A variation of the somatic mutation theory of aging, oncogenic mutations and clonal expansion, but not functional impairment, are postulated as the most relevant consequence of somatic mutations.

Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.

In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls are observed.

Why and how are we living longer?

The reasons for the continuing increase in human life expectancy are examined and prospects for further extending the health span – the period free of age‐related disability and disease – are critically assessed.

Calorie restriction falters in the long run

Resveratrol-Induced Effects on Body Fat Differ Depending on Feeding Conditions

After analyzing the results obtained under overfeeding, normal feeding, and energy restriction conditions, it can be stated that resveratrol is useful in reducing body fat accumulation, and thus preventing obesity.

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

It is demonstrated that GDNF-family receptor α-like (GFRAL), an orphan member of the GFR-α family, is a high-affinity receptor for GDF15 that mediates the metabolic effects of GDF12 and binds to GDF 15 in vitro and is required for the metabolic actions of G DF15 with respect to body weight and food intake in vivo in mice.

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target ofRapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.

pharmacological benefits of exercise. British journal of pharmacology

  • Clinical science
  • 2012

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

It is demonstrated the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence and it is demonstrated that NR delays senescences of neural SCs and melanocyteSCs and increases mouse life span.
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