Rodent-borne hemorrhagic fevers: under-recognized, widely spread and preventable – epidemiology, diagnostics and treatment

  title={Rodent-borne hemorrhagic fevers: under-recognized, widely spread and preventable – epidemiology, diagnostics and treatment},
  author={Marco Goeijenbier and Jiri F. P. Wagenaar and Marga Goris and Byron Martina and Heikki Henttonen and Antti Vaheri and Chantal B.E.M. Reusken and Rudy A. Hartskeerl and Albert D M E Osterhaus and Eric C.M. van Gorp},
  journal={Critical Reviews in Microbiology},
  pages={26 - 42}
This review presents an overview of the most important rodent-borne hemorrhagic fever pathogens directly transmitted from rodents to humans, namely Leptospira and hantaviruses, together with the New- and Old-World arenaviruses. These zoonotic diseases frequently share clinical symptoms, transmission routes and other epidemiological features and often have an emerging pattern. Differential diagnostics could benefit from a syndrome-based approach grouping these pathogens. In this review extensive… 

Emerging infections : haemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome

Important aspects of hantavirus disease focussing on epidemiology, clinical manifestations and (experimental) treatment are discussed.

Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis.

This review aims to provide an overview of EVD for clinicians, with the emphasis on pathogenesis, clinical manifestations, and treatment options.

Molecular detection of viruses causing hemorrhagic fevers in rodents in the south-west of Korea

Investigation of emerging viruses causing hemorrhagic fevers from wild rodents in the Republic of Korea found that virus shedding from A. agrarius can increase the risk of humans contracting HFRS, and may help to predict and prevent disease outbreaks in ROK.

Pathogenic Mechanisms Involved in the Hematological Alterations of Arenavirus-induced Hemorrhagic Fevers

The current knowledge about the hematological alterations present in VHF induced by arenaviruses are presented, including new aspects on the underlying pathogenic mechanisms.

Lassa Fever: A Comprehensive Review

Observed case-fatality rate among patients hospitalized with severe cases of Lassa fever is 15%, and early supportive care with rehydration and symptomatic treatment improves survival.

Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses

Current knowledge regarding animal models employed in the study of human pathogenic hantaviruses and arenviruses is examined, including analysis of infection models in natural reservoirs and the impact of strain heterogeneity on the susceptibility of animals to infection.

Leptospirosis: A re-emerging zoonosis

In the documented epidemics, weather, health and environmental conditions in the geographical region could cause the disease and risk factors related to the disease in different epidemiological scenarios are analysed.

Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk

Rodents are known to be reservoir hosts for at least 60 zoonotic diseases and are known to play an important role in their transmission and spread in different ways. We sampled different rodent

Seoul hantavirus in brown rats in the Netherlands: implications for physicians--Epidemiology, clinical aspects, treatment and diagnostics.

Current knowledge is reviewed on the clinical manifestation of SEOV versus PUUV infections in humans, the treatment of clinical cases and diagnostics, and the high importance of this hantavirus for Public Health in large areas of Europe.

Zoonotic Viruses in Three Species of Voles from Poland

Rodents are known to be reservoir hosts for a plethora of zoonotic viruses and therefore play a significant role in the dissemination of these pathogens, and the distribution and abundance of CPXV in voles in Europe is contributing to understanding.



Rodent-borne emerging viral zoonosis. Hemorrhagic fevers and hantavirus infections in South America.

Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans.

Hantaviruses: immunology, treatment, and prevention.

This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.

Venezuelan hemorrhagic fever: clinical and epidemiological studies of 165 cases.

  • N. de ManzioneR. Salas R. Tesh
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1998
Principal symptoms among the patients with VHF included fever, malaise, headache, arthralgia, sore throat, vomiting, abdominal pain, diarrhea, convulsions, and a variety of hemorrhagic manifestations.

Hantavirus infections: epidemiology and pathogenesis.

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

Current concepts regarding the ecology of and disease associated with these serious human pathogens are presented and an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.

Epidemiology of argentine hemorrhagic fever

Whether the establishment of Junin virus persistence in Calomys musculinus and other reservoirs depends on viral or host factors, such as a selective defect in L3T4+ lymphocytes as recently shown for mice, remains to be explored.

Recent approaches in hantavirus vaccine development

This review will summarize the current knowledge and recent progress as well as new speculative approaches in the development of hantavirus vaccines.

Leptospirosis: a zoonotic disease of global importance.

Tula Virus Infection Associated with Fever and Exanthema After a Wild Rodent Bite

In this case, paronychia, fever and exanthema occurred after the patient was bitten by a wild rodent, indicating an unusual route of hantavirus transmission, and Tula virus infection should be taken into account in patients with appropriate clinical symptoms and contact with rodents.