Rodent animal models of delayed bone healing and non-union formation: a comprehensive review.

  title={Rodent animal models of delayed bone healing and non-union formation: a comprehensive review.},
  author={Patric Garcia and T. Scheuer Histing and J{\"o}rg Holstein and Moritz Klein and Matthias W Laschke and Romano Matthys and Anita Ignatius and Britt Wildemann and Jasmin Lienau and Anja Peters and Bettina M Willie and georg. duda and Lutz Claes and Tim Pohlemann and Michael Dieter Menger},
  journal={European cells & materials},
          1-12; discussion 12-4
Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain a major clinical challenge. Animal models are needed to study the complex process of normal and impaired fracture healing and to develop new therapeutic strategies. Whereas in the past mainly large animals have been used to study normal and impaired fracture healing, nowadays rodent models are of increasing interest. New osteosynthesis techniques for rat and mice have been… CONTINUE READING
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