Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure

@inproceedings{Christ2012RodentAM,
  title={Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure},
  author={Bruno Christ and Sandra Br{\"u}ckner},
  booktitle={Front. Physio.},
  year={2012}
}
Without therapeutic intervention acute liver failure (ALF) is the consequence of a progredient destruction of the liver parenchyma due to metabolic exhaustion of the hepatocytes. Perivenous hepatocytes are responsible for the detoxification of noxious compounds via the cytochrome P450 enzyme system. Liver transplantation is the only remaining therapeutic option in the end-stage of the disease. Assuming that metabolic capacity could be provided by healthy hepatocytes and thus substitute for the… CONTINUE READING
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