Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish.

@article{Saade2013RodPP,
  title={Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish.},
  author={Carole J. Saade and Karen Alvarez-Delf{\'i}n and James M. Fadool},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 5},
  pages={1804-14}
}
Humans are largely dependent upon cone-mediated vision. However, death or dysfunction of rods, the predominant photoreceptor subtype, results in secondary loss of cones, remodeling of retinal circuitry, and blindness. The changes in circuitry may contribute to the vision deficit and undermine attempts at restoring sight. We exploit zebrafish larvae as a genetic model to specifically characterize changes associated with photoreceptor degenerations in a cone-dominated retina. Photoreceptors form… CONTINUE READING

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However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
Rod PhotoreceptorsConstitutional part ofRetina
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
In adults , rods and cones are present in approximately equal numbers , and in pde6c(w59 ) mutants glutamate receptor expression and synaptic structures in the outer plexiform layer are preserved , and visual responses are gained in these once blind fish .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
In adults , rods and cones are present in approximately equal numbers , and in pde6c(w59 ) mutants glutamate receptor expression and synaptic structures in the outer plexiform layer are preserved , and visual responses are gained in these once blind fish .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
Retinal ConeConstitutional part ofRetina
We propose that the abundance of rods in the adult protects the retina from cone degeneration - induced remodeling .
However , death or dysfunction of rods , the predominant photoreceptor subtype , results in secondary loss of cones , remodeling of retinal circuitry , and blindness .
Rod photoreceptors protect from cone degeneration - induced retinal remodeling and restore visual responses in zebrafish .
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