Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches.

@article{Kefalov2012RodAC,
  title={Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches.},
  author={Vladimir J Kefalov},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 3},
  pages={1635-41}
}
Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the… CONTINUE READING

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