Rocky Mountain spotted fever vaccine: a regional need.

  title={Rocky Mountain spotted fever vaccine: a regional need.},
  author={David H Walker and Mario Rubens Guimar{\~a}es Montenegro and Barbara C. Hegarty and Giuseppe Tringali},
  journal={Southern medical journal},
  volume={77 4},
Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in… CONTINUE READING