Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.

  title={Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.},
  author={Bernd Baumann and Frank Bohnenstengel and Daniela Siegmund and Harald Wajant and Christoph Weber and Ingrid Herr and K -M Debatin and Peter Proksch and Thomas Wirth},
  journal={The Journal of biological chemistry},
  volume={277 47},
Crude extracts from different Aglaia species are used as anti-inflammatory remedies in the traditional medicine of several countries from Southeast Asia. Because NF-kappaB transcription factors represent key regulators of genes involved in immune and inflammatory responses, we supposed that the anti-inflammatory effects of Aglaia extracts are mediated by the inhibition of NF-kappaB activity. Purified compounds of Aglaia species, namely 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type… CONTINUE READING
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