Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps.

@article{Shudo2007RobustnessOT,
  title={Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps.},
  author={Emi Shudo and Jin Yang and Akihiko Yoshimura and Yoh Iwasa},
  journal={Journal of theoretical biology},
  year={2007},
  volume={246 1},
  pages={1-9}
}
In the interferon-gamma (IFNgamma)-activated Janus Kinase (JAK)/signal transducer and activator of transcription 1 (STAT1) pathway, multiple steps of STAT1 dimerization are required prior to gene expression that produce antiviral molecules. By interpreting experimental results, an existing mathematical model suggested that only phosphorylated STAT1 dimers… CONTINUE READING