Robustness of positional specification by the Hedgehog morphogen gradient.

@article{Irons2010RobustnessOP,
  title={Robustness of positional specification by the Hedgehog morphogen gradient.},
  author={David J. Irons and Alexandre Wojcinski and Bruno Glise and Nicholas A. M. Monk},
  journal={Developmental biology},
  year={2010},
  volume={342 2},
  pages={180-93}
}
Spatial gradients of Hedgehog signalling play a central role in many patterning events during animal development, regulating cell fate determination and tissue growth in a variety of tissues and developmental stages. Experimental evidence suggests that many of the proteins responsible for regulating Hedgehog signalling and transport are themselves targets of Hedgehog signalling, leading to multiple levels of feedback within the system. We use mathematical modelling to analyse how these… CONTINUE READING

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