Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling

  title={Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling},
  author={Sarah Filippi and Chris P. Barnes and Paul D. W. Kirk and Takamasa Kudo and Katsuyuki Kunida and Siobhan S. McMahon and Takaho Tsuchiya and Takumi Wada and Shinya Kuroda and Michael P. H. Stumpf},
  booktitle={Cell reports},
Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically identical cells. This affects how individual cells respond differentially to the same environmental stimulus. However, the origins of cell-to-cell variability in cellular signaling systems remain poorly understood. Here, we measure the dynamics of phosphorylated MEK and ERK across cell populations and quantify the levels of population heterogeneity over time using high-throughput image cytometry. We use… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 20 times. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Modeling of cytometry data in logarithmic space: When is a bimodal distribution not bimodal?

Cytometry. Part A : the journal of the International Society for Analytical Cytology • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 14 references

Sequential Monte Carlo samplers

A. Doucet P. Del Moral, Ajay Jasra
View 4 Excerpts
Highly Influenced

Reverse engineering genetic networks using the GeneNet package

J. Schäfer, R. Opgen-Rhein, K. Strimmer
Journal of the American Statistical Association 96, 1151–1160. • 2001
View 3 Excerpts
Highly Influenced

Unscented approaches to inference and design for systems and synthetic biology

D. Silk
PhD thesis, Imperial College London. • 2013
View 1 Excerpt

Statistical Analysis Of Network Data: Methods And Models

E. D. Kolaczyk
Springer. • 2009
View 2 Excerpts

Similar Papers

Loading similar papers…