Robustness of Inference of Haplotype Block Structure

  title={Robustness of Inference of Haplotype Block Structure},
  author={Russell Schwartz and Bjarni V. Halld{\'o}rsson and Vineet Bafna and Andrew G. Clark and Sorin Istrail},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={10 1},
In this report, we examine the validity of the haplotype block concept by comparing block decompositions derived from public data sets by variants of several leading methods of block detection. We first develop a statistical method for assessing the concordance of two block decompositions. We then assess the robustness of inferred haplotype blocks to the specific detection method chosen, to arbitrary choices made in the block-detection algorithms, and to the sample analyzed. Although the block… CONTINUE READING

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