Robustness measure for an adeno-associated viral shell self-assembly is accurately predicted by configuration space atlasing using EASAL

@inproceedings{Wu2012RobustnessMF,
  title={Robustness measure for an adeno-associated viral shell self-assembly is accurately predicted by configuration space atlasing using EASAL},
  author={Ruijin Wu and Aysegul Ozkan and Antonette Bennett and Mavis Agbandje-McKenna and Meera Sitharam},
  booktitle={BCB},
  year={2012}
}
Viral shell assembly occurs spontaneously in solution, caused by weak inter-atomic interactions between the identical coat-protein monomers that constitute the shell. A sound measure of robustness of the assembly process is therefore based on determining the weak interactions whose disruption significantly disrupts successful assembly. We used data isolated from the X-ray structure of a T=1, Adeno-Associated Virus as input to a new software suite of algorithms, EASAL, (Efficient Atlasing and… CONTINUE READING