Robustness and power of the unified model in the analysis of quantitative measurements.

@article{Demenais1986RobustnessAP,
  title={Robustness and power of the unified model in the analysis of quantitative measurements.},
  author={Florence Demenais and Mark Lathrop and J. M. Lalouel},
  journal={American journal of human genetics},
  year={1986},
  volume={38 2},
  pages={228-34}
}
The resolution between skewness in the distribution of a quantitative trait and segregation of a major gene is a difficult issue in family studies. Quantitative data were simulated on six-member nuclear families in order to study the behavior of the unified model under these circumstances. Replicates of 100 nuclear families were generated assuming a multifactorial model with skewness. In the range where a major gene was falsely detected in 80%-100% of the simulations analyzed under the… CONTINUE READING