Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway

@article{Krantz2009RobustnessAF,
  title={Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway},
  author={Marcus Krantz and Doryaneh Ahmadpour and L Ottosson and Jonas Warringer and Christian Waltermann and Bodil Nordlander and Edda Klipp and Anders Blomberg and Stefan Hohmann and Hiroaki Kitano},
  journal={Molecular Systems Biology},
  year={2009},
  volume={5},
  pages={281 - 281}
}
Cellular signalling networks integrate environmental stimuli with the information on cellular status. These networks must be robust against stochastic fluctuations in stimuli as well as in the amounts of signalling components. Here, we challenge the yeast HOG signal-transduction pathway with systematic perturbations in components' expression levels under various external conditions in search for nodes of fragility. We observe a substantially higher frequency of fragile nodes in this signal… CONTINUE READING