Robustness—it's not where you think it is

  title={Robustness—it's not where you think it is},
  author={Ken Wolfe},
  journal={Nature Genetics},
  • K. Wolfe
  • Published 1 May 2000
  • Biology
  • Nature Genetics
A new study indicates that closely related genes in yeast may be less redundant than expected. Instead, the stability of genetic networks—which buffers the deleterious effect of mutations—may be due to the actions of unrelated genes. 

Identification of novel conserved peptide uORF homology groups in Arabidopsis and rice reveals ancient eukaryotic origin of select groups and preferential association with transcription factor-encoding genes

Conservation of uORF amino acid sequence, association with homologous mORFs over long evolutionary time periods, preferential retention after whole genome duplications, and preferential association with m ORFs coding for transcription factors suggest that the conserved peptide uORFs identified in this study are strong candidates for translational controllers of regulatory genes.

Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain‐to‐bone signaling pathway

A model for evolution of bone homeostasis in the context of the vertebrate transition from an aquatic to a terrestrial lifestyle is proposed and Pth4, an ancient parathyroid hormone lost in eutherian mammals, is revealed, revealing a new brain‐to‐bone signaling pathway.

Contribution of nonohnologous duplicated genes to high habitat variability in mammals.

It is shown that the proportion of small-scale duplication (SSD) genes in the genome, but not that of WGD genes, is significantly correlated with habitat variability, and species with low habitat variability have a higher proportion of lost duplicated genes, particularly SSD genes, than those with high habitat variability.

The lhfpl5 ohnologs lhfpl5a and lhfpl5b are required for mechanotransduction in distinct populations of sensory hair cells in zebrafish

The data suggest that targeting of Tmc1 and Tmc2b proteins to stereocilia in zebrafish hair cells occurs independently of Lhfpl5 proteins, and corroborates the evolutionarily conserved co-dependence between Lh fpl5 and Pcdh15, but also reveals novel requirements for Cdh23 and Myo7aa to correctly localize LhFpl5a.

Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish

Biochemical and immunochemical analyses demonstrate that zebrafish Plin6 protein targets the surface of pigment-containing carotenoid droplets (CD) and Ultrastructural and functional analyses indicate that LD and CD are homologous structures, and that Plin 6 was functionalized early in vertebrate evolution for concentrating and trafficking pigment.

PTH Reloaded: A New Evolutionary Perspective

Comparison between PTH peptides of fish and mammals allows us to discuss an evolutionary model for PTH functions related to bone mineral balance during the vertebrate transition from an aquatic to a terrestrial environment.

Molecular evolution of the ependymin-related gene epdl2 in African weakly electric fish

The findings strongly imply that epdl2 genes display signatures of selection-driven functional specialization after tandem duplications in the rapidly speciating Paramormyrops, an important aspect of species recognition during mating.

OP-MOLB210106 3308..3331

This study provides the first genome-wide, multispecies analysis of the mechanisms influencing metazoan miRNA evolution after whole-genome duplication, and reveals both conserved and divergent expression patterns across species in line with miRNA functions in phenotypic canalization and diversification.

Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos

Kir channels are essential for normal potassium homeostasis, maintaining the cellular resting membrane potential, and regulating electrolyte transportation and expression and functions during embryonic development remain largely unknown.



The yeast genome project: what did we learn?

  • B. Dujon
  • Biology
    Trends in genetics : TIG
  • 1996

Yeast genome evolution in the post-genome era.

On some principles governing molecular evolution.

  • M. KimuraT. Ohta
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1974
Five Pillars of Evolution were culled from the accumulated evidence on molecular evolution and theoretical considerations of the population dynamics of mutant substitutions.

Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real.

The expression of the AAD genes was found to be induced by chemicals that cause an oxidative shock by inactivating the glutathione reservoir of the cells, and it was found that the response to anti-GSH agents was Yap1p dependent.

Robustness against mutations in genetic networks of yeast

It is demonstrated that interactions among unrelated genes are the major cause of robustness against mutations, which is probably an evolved response of genetic networks to stabilizing selection.

Evolution by Gene Duplication

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.

A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.

Functional Analysis of the Genes of Yeast Chromosome V by Genetic Footprinting

Genetic footprinting was used to assess the phenotypic effects of Ty1 transposon insertions in 268 predicted genes of chromosome V of Saccharomyces cerevisiae, and new mutant phenotypes were identified.