Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein

@article{Bershtein2006RobustnessepistasisLS,
  title={Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein},
  author={S. Bershtein and M. Segal and R. Bekerman and N. Tokuriki and Dan S. Tawfik},
  journal={Nature},
  year={2006},
  volume={444},
  pages={929-932}
}
The distribution of fitness effects of protein mutations is still unknown. Of particular interest is whether accumulating deleterious mutations interact, and how the resulting epistatic effects shape the protein’s fitness landscape. Here we apply a model system in which bacterial fitness correlates with the enzymatic activity of TEM-1 β-lactamase (antibiotic degradation). Subjecting TEM-1 to random mutational drift and purifying selection (to purge deleterious mutations) produced changes in its… Expand
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