Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.

Abstract

The NS3 helicase is essential for replication of the hepatitis C virus. This multifunctional Superfamily 2 helicase protein unwinds nucleic acid duplexes in a stepwise, ATP-dependent manner. Although kinetic features of its mechanism are beginning to emerge, little is known about the physical determinants for NS3 translocation along a strand of nucleic acid… (More)

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Cite this paper

@article{Beran2006RobustTA, title={Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.}, author={Rudolf K. F. Beran and Michael M. Bruno and Heath A Bowers and Eckhard Jankowsky and Anna Marie Pyle}, journal={Journal of molecular biology}, year={2006}, volume={358 4}, pages={974-82} }