Robust transcriptional tumor signatures applicable to both formalin-fixed paraffin-embedded and fresh-frozen samples

@inproceedings{Chen2017RobustTT,
  title={Robust transcriptional tumor signatures applicable to both formalin-fixed paraffin-embedded and fresh-frozen samples},
  author={Rou Chen and Qingzhou Guan and Jun Cheng and Jun He and Huaping Liu and Hao Cai and Guini Hong and Jiahui Zhang and Na Li and Lu Ao and Zheng Guo},
  booktitle={Oncotarget},
  year={2017}
}
Formalin-fixed paraffin-embedded (FFPE) samples represent a valuable resource for clinical researches. However, FFPE samples are usually considered an unreliable source for gene expression analysis due to the partial RNA degradation. In this study, through comparing gene expression profiles between FFPE samples and paired fresh-frozen (FF) samples for three cancer types, we firstly showed that expression measurements of thousands of genes had at least two-fold change in FFPE samples compared… CONTINUE READING

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