Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis

@article{Choi2005RobustSO,
  title={Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis},
  author={Sun Shim Choi and Weimin Li and Bruce T. Lahn},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={1367-1371}
}
The structure of a protein depends critically on the complex interactions among its amino acid residues. It has long been hypothesized that interacting residues might tend to coevolve, but it is not known whether such coevolution is a general phenomenon across the proteome. Here, we describe a novel methodology called phylogeny-aided structural analysis, which uncovers robust signals of interacting-residue coevolution in mammalian proteomes. Furthermore, this new method allows the magnitude of… CONTINUE READING

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overview and issues

  • A. D. Mackerell, Jr. Empirical force fields for biological macromolecules
  • J. Comput. Chem. 25, 1584–1604
  • 2004

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