Robust multipoint identical-by-descent mapping for affected relative pairs.

@article{Schaid2005RobustMI,
  title={Robust multipoint identical-by-descent mapping for affected relative pairs.},
  author={Daniel J. Schaid and Jason P. Sinnwell and Stephen N. Thibodeau},
  journal={American journal of human genetics},
  year={2005},
  volume={76 1},
  pages={128-38}
}
The genetic mapping of complex traits has been challenging and has required new statistical methods that are robust to misspecified models. Liang et al. proposed a robust multipoint method that can be used to simultaneously estimate, on the basis of sib-pair linkage data, both the position of a trait locus on a chromosome and its effect on disease status. The advantage of their method is that it does not require specification of an underlying genetic model, so estimation of the position of a… CONTINUE READING