Robust mixed 10/12 helices promoted by "alternating chirality" in a new family of C-linked carbo-beta-peptides.

@article{Sharma2003RobustM1,
  title={Robust mixed 10/12 helices promoted by "alternating chirality" in a new family of C-linked carbo-beta-peptides.},
  author={Gangavaram V M Sharma and Kondreddi Ravinder Reddy and Palakodety Radha Krishna and Ampapathi Ravi Sankar and Kongari Narsimulu and Singarapu Kiran Kumar and Pagadala Jayaprakash and Bulusu Jagannadh and Ajit Chand Kunwar},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 45},
  pages={13670-1}
}
The C-linked carbo-beta-peptides, oligomers of a new class of C-linked carbo-beta3-amino acids, have been shown to generate mixed 12/10 and 10/12 helices. The design involves use of "alternating chirality" of the epimeric (at the amine center) monomers to control the stability of these helices. The observation of stable 12/10 helix in a tripeptide and 10/12 helix in a tetrapeptide is unprecedented. 

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