Robust method optimization strategy-a useful tool for method transfer: the case of SFC.


The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design Space (DS) was introduced in the field of analytical method optimization. In chromatographic words, the DS is the space of chromatographic conditions that… (More)
DOI: 10.1016/j.jpba.2013.09.030


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