Robust meta-analysis of gene expression using the elastic net

  title={Robust meta-analysis of gene expression using the elastic net},
  author={Jacob J. Hughey and Atul J Butte},
  booktitle={Nucleic acids research},
Meta-analysis of gene expression has enabled numerous insights into biological systems, but current methods have several limitations. We developed a method to perform a meta-analysis using the elastic net, a powerful and versatile approach for classification and regression. To demonstrate the utility of our method, we conducted a meta-analysis of lung cancer gene expression based on publicly available data. Using 629 samples from five data sets, we trained a multinomial classifier to… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2002
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