Robust gut-specific gene expression in transgenic Aedes aegypti mosquitoes.

  title={Robust gut-specific gene expression in transgenic Aedes aegypti mosquitoes.},
  author={Luciano Andrade Moreira and Marten J. Edwards and Farzaneh Adhami and Nijole Jasinskiene and Anthony A. James and Marcelo Jacobs-Lorena},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 20},
Genetic modification of the vectorial capacity of mosquito vectors of human disease requires promoters capable of driving gene expression with appropriate tissue and stage specificity. We report on the characterization in transgenic Aedes aegypti of two mosquito gut-specific promoters. A 1.4-kb DNA fragment adjacent to the 5' end of the coding region of the Ae. aegypti carboxypeptidase (AeCP) gene and a corresponding 3.4-kb DNA fragment at the 5' end of the Anopheles gambiae carboxypeptidase… CONTINUE READING
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