Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms

@article{Hattori2009RobustDB,
  title={Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms},
  author={D. Hattori and Yi Yu Chen and Benjamin J Matthews and Lukasz Salw{\'i}nski and Chiara Sabatti and Wesley B Grueber and S Lawrence Zipursky},
  journal={Nature},
  year={2009},
  volume={461},
  pages={644-648}
}
Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily. In Drosophila, Dscam1 generates 19,008 different ectodomains by alternative splicing of three exon clusters, each encoding half or a complete variable immunoglobulin domain. Identical isoforms bind to each other, but rarely to isoforms differing at any one of the variable immunoglobulin domains. Binding between isoforms on opposing membranes promotes repulsion. Isoform… CONTINUE READING

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