Robust control of mitotic spindle orientation in the developing epidermis

@inproceedings{Poulson2010RobustCO,
  title={Robust control of mitotic spindle orientation in the developing epidermis},
  author={Nicholas D. Poulson and Terry Lechler},
  booktitle={The Journal of cell biology},
  year={2010}
}
Progenitor cells must balance self-amplification and production of differentiated progeny during development and homeostasis. In the epidermis, progenitors divide symmetrically to increase surface area and asymmetrically to promote stratification. In this study, we show that individual epidermal cells can undergo both types of division, and therefore, the balance is provided by the sum of individual cells' choices. In addition, we define two control points for determining a cell's mode of… CONTINUE READING
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