Robust and efficient design of experiments for the Monod model.

  title={Robust and efficient design of experiments for the Monod model.},
  author={Holger Dette and Viatcheslav B. Melas and Andrey Pepelyshev and Nikolay S. Strigul},
  journal={Journal of theoretical biology},
  volume={234 4},
In this paper the problem of designing experiments for the Monod model, which is frequently used in microbiology, is studied. The model is defined implicitly by a differential equation and has numerous applications in microbial growth kinetics, environmental research, pharmacokinetics, and plant physiology. The designs presented so far in the literature are local optimal designs, which depend sensitively on a preliminary guess of the unknown parameters, and are for this reason in many cases not… CONTINUE READING

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