Robust Sampling of Altered Pathways for Drug Repositioning Reveals Promising Novel Therapeutics for Inclusion Body Myositis

  title={Robust Sampling of Altered Pathways for Drug Repositioning Reveals Promising Novel Therapeutics for Inclusion Body Myositis},
  author={Juan Luis Fern{\'a}ndez-Mart{\'i}nez and {\'O}scar {\'A}lvarez and Enrique J. deAndr{\'e}s-Galiana and Javier Vi{\~n}a and L. Huergo},
  journal={Journal of Rare Diseases Research \& Treatment},
In this paper we present a robust methodology to deal with phenotype prediction problems associated to drug repositioning in rare diseases, which is based on the robust sampling of altered pathways. We show the application to the analysis of IBM (Inclusion Body Myositis) providing new insights about the mechanisms involved in its development: cytotoxic CD8 T cell-mediated immune response and pathogenic protein accumulation in myofibrils related to the proteasome inhibition. The originality of… Expand
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PGPM_A_205082 105..119
Óscar Álvarez-Machancoses Enrique J DeAndrés Galiana Ana Cernea J Fernández de la Viña Juan Luis Fernández-Martínez 2 1Group of Inverse Problems, Optimization and Machine Learning, Department ofExpand


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