Robust Quantification of Polymerase Chain Reactions Using Global Fitting

@inproceedings{Carr2012RobustQO,
  title={Robust Quantification of Polymerase Chain Reactions Using Global Fitting},
  author={Ana C. Carr and Sean D Moore},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Quantitative polymerase chain reactions (qPCR) are used to monitor relative changes in very small amounts of DNA. One drawback to qPCR is reproducibility: measuring the same sample multiple times can yield data that is so noisy that important differences can be dismissed. Numerous analytical methods have been employed that can extract the relative template abundance between samples. However, each method is sensitive to baseline assignment and to the unique shape profiles of… CONTINUE READING
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