Robust PBPK/PD-Based Model Predictive Control of Blood Glucose

@article{Schaller2016RobustPM,
  title={Robust PBPK/PD-Based Model Predictive Control of Blood Glucose},
  author={Stephan Schaller and J{\"o}rg Lippert and Lukas Schaupp and Thomas R. Pieber and Andreas Schuppert and Thomas Eissing},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2016},
  volume={63},
  pages={1492-1504}
}
Goal: Automated glucose control (AGC) has not yet reached the point where it can be applied clinically [3]. Challenges are accuracy of subcutaneous (SC) glucose sensors, physiological lag times, and both inter- and intraindividual variability. To address above issues, we developed a novel scheme for MPC that can be applied to AGC. Results: An individualizable generic whole-body physiology-based pharmacokinetic and dynamics (PBPK/PD) model of the glucose, insulin, and glucagon metabolism has… CONTINUE READING
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Citations

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SHOWING 1-9 OF 9 CITATIONS

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  • 2017 21st International Conference on Process Control (PC)
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

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  • 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  • 2016
VIEW 1 EXCERPT
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Closing the loop: the adicol experience.

  • Diabetes technology & therapeutics
  • 2004
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A comparative effectiveness analysis of three continuous glucose monitors: The navigator, G4 Platinum, and enlite

E. R. Damiano
  • J. Diabetes Sci. Technol., vol. 8, pp. 699–708, Apr. 21, 2014.
  • 2014
VIEW 2 EXCERPTS

Automated control of an adaptive bihormonal, dual-sensor artificial pancreas and evaluation during inpatient studies

P. G. Jacobs
  • IEEE Trans. Biomed. Eng., vol. 61, no. 10, pp. 2569–2581, Oct. 2014.
  • 2014
VIEW 1 EXCERPT

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