Robust Identification of Noncoding RNA from Transcriptomes Requires Phylogenetically-Informed Sampling

  title={Robust Identification of Noncoding RNA from Transcriptomes Requires Phylogenetically-Informed Sampling},
  author={Stinus Lindgreen and Sinan Uğur Umu and Alicia Sook-Wei Lai and Hisham Eldai and Wenting Liu and Stephanie McGimpsey and Nicole E. Wheeler and Patrick J. Biggs and Nicholas R Thomson and Lars Barquist and Anthony M. Poole and Paul P. Gardner},
  booktitle={PLoS Computational Biology},
Noncoding RNAs are integral to a wide range of biological processes, including translation, gene regulation, host-pathogen interactions and environmental sensing. While genomics is now a mature field, our capacity to identify noncoding RNA elements in bacterial and archaeal genomes is hampered by the difficulty of de novo identification. The emergence of new technologies for characterizing transcriptome outputs, notably RNA-seq, are improving noncoding RNA identification and expression… CONTINUE READING
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