Robust Association Tests Under Different Genetic Models, Allowing for Binary or Quantitative Traits and Covariates

@inproceedings{So2011RobustAT,
  title={Robust Association Tests Under Different Genetic Models, Allowing for Binary or Quantitative Traits and Covariates},
  author={H C So and Pak C. Sham},
  booktitle={Behavior genetics},
  year={2011}
}
The association of genetic variants with outcomes is usually assessed under an additive model, for example by the trend test. However, misspecification of the genetic model will lead to a reduction in power. More robust tests for association might therefore be preferred. A useful approach is to consider the maximum of the three test statistics under additive, dominant and recessive models (MAX3). The p-value however has to be adjusted to maintain the type I error rate. Previous studies and… CONTINUE READING
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