Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile.

@article{Pendse2010RobustUG,
  title={Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile.},
  author={Gautam V. Pendse and Adam J Schwarz and Richard Baumgartner and Alexandre Coimbra and Jaymin Upadhyay and David Borsook and Lino Becerra},
  journal={Journal of magnetic resonance imaging : JMRI},
  year={2010},
  volume={31 6},
  pages={1445-57}
}
PURPOSE To determine a simple yet robust method to generate parsimonious design matrices that accurately estimate the "pharmacological MRI" (phMRI) response amplitude in the presence of both confounding signals and variability in temporal profile. Variability in the temporal response profile of phMRI time series data is often observed. If not properly accounted for, this variation can result in inaccurate and unevenly biased signal amplitude estimates when modeled within a general linear model… CONTINUE READING