Robotic multiwell planar patch-clamp for native and primary mammalian cells

  title={Robotic multiwell planar patch-clamp for native and primary mammalian cells},
  author={Carol J. Milligan and Jing Li and P. Ram Sukumar and Yasser Majeed and Mark L Dallas and Anne English and Paul F. Emery and Karen E Porter and Andrew M Smith and Ian McFadzean and Dayne Beccano-Kelly and Yahya M. Bahnasi and Alex Cheong and Jacqueline Naylor and Fanning Zeng and Xing Liu and Nikita Gamper and Lin-Hua Jiang and Hugh A. Pearson and Chris S Peers and Brian Robertson and David J Beech},
  journal={Nature Protocols},
Robotic multiwell planar patch-clamp has become common in drug development and safety programs because it enables efficient and systematic testing of compounds against ion channels during voltage-clamp. It has not, however, been adopted significantly in other important areas of ion channel research, where conventional patch-clamp remains the favored method. Here, we show the wider potential of the multiwell approach with the ability for efficient intracellular solution exchange, describing… CONTINUE READING


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patch clamping made easy

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