Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

  title={Robo4 signaling in endothelial cells implies attraction guidance mechanisms.},
  author={Sukhbir Kaur and Maria Domenica Castellone and Victoria M. Bedell and Martha Konar and J. Silvio Gutkind and Ramani Ramchandran},
  journal={The Journal of biological chemistry},
  volume={281 16},
Roundabouts (robo) are cell-surface receptors that mediate repulsive signaling mechanisms at the central nervous system midline. However, robos may also mediate attraction mechanisms in the context of vascular development. Here, we have performed structure-function analysis of roundabout4 (Robo4), the predominant robo expressed in embryonic zebrafish vasculature and found by gain of function approaches in vitro that Robo4 activates Cdc42 and Rac1 Rho GTPases in endothelial cells. Indeed… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 48 extracted citations

Role of ROBO4 Signalling in Developmental and Pathological Angiogenesis

BioMed research international • 2014
View 9 Excerpts
Highly Influenced


Publications referenced by this paper.

The Zebrafish Book, 4th Ed

M. Westerfield

Similar Papers

Loading similar papers…