Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.

@article{Yoshikawa2013Robo4IA,
  title={Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.},
  author={Mai Yoshikawa and Yohei Mukai and Yoshiaki Okada and Yuki Tsumori and Shin-ichi Tsunoda and Yasuo M Tsutsumi and William C. Aird and Yasuo Yoshioka and Naoki Okada and Takefumi Doi and Shinsaku Nakagawa},
  journal={Blood},
  year={2013},
  volume={121 14},
  pages={2804-13}
}
Monoclonal antibodies (mAbs) that are internalized into cells are a current focus in the development of antibody-drug conjugates (ADCs). We describe a phage display-based high-throughput screening system to rapidly isolate cell-internalizing mAbs. We simultaneously examined the cell-internalizing activities of several hundred independent mAbs and successfully isolated cell-internalizing mAbs against the tumor endothelial markers Roundabout homolog 4 (Robo4) and vascular endothelial growth… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 50 references

Targeting tumor-associated endothelial cells: anti-VEGFR2 immunoliposomes mediate tumor vessel disruption and inhibit tumor growth.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012
View 1 Excerpt

Congestive heart failure risk in patients with breast cancer treated with bevacizumab.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2011

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