Roberts' syndrome. I. Cytological evidence for a disturbance in chromatid pairing.

@article{German1979RobertsSI,
  title={Roberts' syndrome. I. Cytological evidence for a disturbance in chromatid pairing.},
  author={James German},
  journal={Clinical genetics},
  year={1979},
  volume={16 6},
  pages={441-7}
}
In the rare developmental disorder Roberts' syndrome, prophase and metaphase chromosomes display premature sister-chromatid separation, most prominently at certain regions in which the chromatin is composed of highly reiterated base sequences. In addition, interphase nuclei present a striking distortion in their contours. The observed abnormalities are interpreted as evidence for the presence of a genetically determined disturbance affecting the normal mechanisms for pairing and disjoining of… CONTINUE READING

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