# Robert Rosen’s Work and Complex Systems Biology

@article{Bianu2006RobertRW, title={Robert Rosen’s Work and Complex Systems Biology}, author={Ion C. Băianu}, journal={Axiomathes}, year={2006}, volume={16}, pages={25-34} }

Complex Systems Biology approaches are here considered from the viewpoint of Robert Rosen’s (M,R)-systems, Relational Biology and Quantum theory, as well as from the standpoint of computer modeling. Realizability and Entailment of (M,R)-systems are two key aspects that relate the abstract, mathematical world of organizational structure introduced by Rosen to the various physicochemical structures of complex biological systems. Their importance for understanding biological function and life…

## 33 Citations

Rosen’s (M,R) system in process algebra

- BiologyBMC Systems Biology
- 2013

It is argued that the behaviour of (M,R) in Bio-PEPA shows life-like properties, which suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes.

Metabolic, Replication and Genomic Category of Systems in Biology, Bioinformatics and Medicine

- Biology
- 2012

Theoreticians of life’s origins postulated that Life on Earth has begun with the simplest possible organism, called the primordial, and mathematicians interested in biology attempted to answer this important question of the minimal living organism by defining the functional relations that would have made life possible in such a minimal system.

Category of Metabolic-Replication Systems in Biology and Medicine

- Medicine
- 2012

Metabolic-repair models, or (M,R)-systems were introduced in Relational Biology by Robert Rosen in terms of categories of sets, deliberately selected without any structure other than the discrete topology of sets.

files: Acomarev34TAO1pt10 .tex CATEGORICAL ONTOLOGY OF COMPLEX SYSTEMS, META–SYSTEMS AND LEVELS: THE EMERGENCE OF LIFE, HUMAN CONSCIOUSNESS AND SOCIETY

- Philosophy
- 2009

The task of developing novel and improved methodological tools for a categorical ontology of complex spacetime structures and the ontological theory of levels is here considered from several…

From Simple to Complex and Ultra-complex Systems: A Paradigm Shift Towards Non-Abelian Systems Dynamics

- Biology
- 2010

It is proposed that super-complexity requires at least four different categorical frameworks, provided by the theories of levels of reality, chronotopoids, (generalized) interactions, and anticipation.

Understanding Systems Biology: A Place for Social Science Analysis

- Biology
- 2015

A broad analysis of this new approach to systems biology was undertaken from the social and cultural studies of science perspective, the results of which are laid down in this book.

Finite Universe of Discourse:The Systems Biology of Walter Elsasser (1904-1991)

- Art
- 2008

Walter Elsasser (1904-1991), an eminent quantum physicist and geophysicist, was also active in theoretical biology over a 35-year period from the early 1950s to the late 1980s. Although increasingly…

Complex Non-linear Biodynamics in Categories, Higher Dimensional Algebra and Łukasiewicz–Moisil Topos: Transformations of Neuronal, Genetic and Neoplastic Networks

- Philosophy
- 2006

A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–Moisil Algebraic–Logic models of non-linear dynamics in complex functional genomes and cell interactomes is proposed, avoiding well known logical paradoxes occurring with sets.

FROM SIMPLE TO HIGHLY-COMPLEX SYSTEMS : A PARADIGM SHIFT TOWARDS NON-ABELIAN EMERGENT SYSTEM DYNAMICS AND META-LEVELS

- Mathematics
- 2011

The evolution of non-linear dynamical system theory and super-complex systems–that are defined by classes of variable topologies and their associated transformations–is presented from a categorial…

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A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–Moisil Algebraic–Logic models of non-linear dynamics in complex functional genomes and cell interactomes is proposed, avoiding well known logical paradoxes occurring with sets.

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