Roads to survival: insulin-like growth factor-1 signaling pathways in cardiac muscle.

@article{Wang2001RoadsTS,
  title={Roads to survival: insulin-like growth factor-1 signaling pathways in cardiac muscle.},
  author={Ping Wang},
  journal={Circulation research},
  year={2001},
  volume={88 6},
  pages={552-4}
}
  • Ping Wang
  • Published 2001 in Circulation research
I nsulin-like growth factor-1 (IGF-1) plays a role in the regulation of myocardial structure and function. IGF-1 is capable of improving cardiac muscle survival, growth, calcium signaling, and differentiation. 1 Among various actions of IGF-1 on heart, the ability of IGF-1 to counteract apoptosis of cardiomyocytes has drawn significant attention in recent years. IGF-1 suppresses myocardial apoptosis and improves myocardial function in various models of experimental cardiomyopathy. 2–5 Compared… CONTINUE READING

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